Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia [Source:SGD;Acc:S000005012]

Chromosome XIV: 495,701-498,289 reverse strand.

R64-1-1:BK006947.3

This gene has 1 transcript (splice variant), 324 orthologues and 3 paralogues.

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