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About the Ashbya gossypii genome
More than 90% of Ashbya gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. It was originally isolated from cotton as a pathogen causing stigmatomycosis by Ashby and Novell in 1926. The Ashbya gossypii genome project was initiated when conservation of gene order and orientation (synteny) to Saccharomyces cerevisiae was noted.
Ashbya gossypii became recognized as an attractive model to study the growth of long and multinucleate fungal cells (hyphae) because of its small genome, haploid nuclei, and efficient gene targeting methods. It is generally assumed that a better understanding of filamentous fungal growth will greatly stimulate the development of novel fungicides.
Annotation
Annotation of Ashbya gossypii was imported from the European Nucleotide Archive. Non coding RNA genes have been annotated using tRNAScan-SE (Lowe, T.M. and Eddy, S.R. 1997), RFAM (Griffiths-Jones et al 2005), and RNAmmer (Lagesen K.,et al 2007); additional analysis tools have also been applied.
References
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Fred S. Dietrich, Sylvia Voegeli, Sophie Brachat, Anita Lerch, Krista Gates, Sabine Steiner, Christine Mohr, Rainer Pöhlmann, Philippe Luedi, Sangdun Choi, Rod A. Wing, Albert Flavier, Thomas D. Gaffney, Peter Philippsen
The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome
Science 9 April 2004:
Pubmed: 15001715
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