Saccharomyces cerevisiae (R64-1-1)

RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant [Source:SGD;Acc:S000004802]


Chromosome XIII: 640,915-645,258 reverse strand.


About this gene

This gene has 1 transcript (splice variant) and 378 orthologues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
P35187 -Ensembl Canonical