RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant [Source:SGD;Acc:S000004802]

Chromosome XIII: 640,915-645,258 reverse strand.

This transcript has 1 exon, is annotated with 51 domains and features and is associated with 88 variant alleles.

This transcript is a product of gene YMR190C Show transcript tableHide transcript table