Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers [Source:SGD;Acc:S000004410]
Chromosome XII: 956,914-958,095 reverse strand.
R64-1-1:BK006945.2
This gene has 1 transcript (splice variant) and 340 orthologues.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
CDC73 | YLR418C_mRNA | 1182 | 393aa | YLR418C | Protein coding | Q06697 | - | Ensembl Canonical, |