Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress; co-expression of human CDC7 and DBF4 complements single cdc7 or dbf4 null mutations or the cdc7 dbf4 double null mutation [Source:SGD;Acc:S000002459]
DNA52, LSD7
Chromosome IV: 558,511-560,625 reverse strand.
R64-1-1:BK006938.2
This gene has 1 transcript (splice variant), 308 orthologues and is a member of 1 Ensembl protein family.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
DBF4 | YDR052C_mRNA | 2115 | 704aa | YDR052C | Protein coding | P32325 | - | Ensembl Canonical, |