DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature [Source:SGD;Acc:S000002323]

MMS8

Chromosome IV: 164,987-167,254 reverse strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 362 orthologues, 1 paralogue and is a member of 1 Ensembl protein family.

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