DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature [Source:SGD;Acc:S000002323]

Chromosome IV: 164,987-167,254 reverse strand.

This transcript has 1 exon, is annotated with 26 domains and features, is associated with 34 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YDL164C Show transcript tableHide transcript table