DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress [Source:SGD;Acc:S000003626]

Chromosome X: 262,757-265,051 reverse strand.

This transcript has 1 exon, is annotated with 30 domains and features, is associated with 56 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YJL090C Show transcript tableHide transcript table