DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074]

LSD1, MEC2, SPK1

Chromosome XVI: 261,727-264,192 reverse strand.

R64-1-1:BK006949.2

This gene has 1 transcript (splice variant), 265 orthologues and 2 paralogues.

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