Saccharomyces cerevisiae (R64-1-1)
Description

DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074]

Synonyms

LSD1, MEC2, SPK1

Location

Chromosome XVI: 261,727-264,192 reverse strand.

R64-1-1:BK006949.2

About this gene

This gene has 1 transcript (splice variant), 327 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
RAD53YPL153C_mRNA2466821aaYPL153C
 
Protein coding
P22216 NM_001183967.1
NP_015172.1

Gene-based displays