Saccharomyces cerevisiae (R64-1-1)
Description

DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074]

Location
About this transcript

This transcript has 1 exon, is annotated with 32 domains and features, is associated with 41 variant alleles and maps to 29 oligo probes.

Gene

This transcript is a product of gene YPL153C Show transcript tableHide transcript table

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
RAD53YPL153C_mRNA2466821aaYPL153C
 
Protein coding
P22216 NM_001183967.1
NP_015172.1
Statistics

Exons: 1, Coding exons: 1, Transcript length: 2,466 bps, Translation length: 821 residues

Uniprot

This transcript corresponds to the following Uniprot identifiers: P22216

Version

YPL153C_mRNA

Type

Protein coding

Annotation Method

Annotation imported from SGD

Transcript-based displays