Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress [Source:SGD;Acc:S000005116]

Chromosome XIV: 310,636-315,882 forward strand.

R64-1-1:BK006947.3

This gene has 1 transcript (splice variant), 356 orthologues and is a member of 1 Ensembl protein family.

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