Saccharomyces cerevisiae (R64-1-1)
Description

Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant [Source:SGD;Acc:S000005032]

Synonyms

TOR3, TRF3

Location

Chromosome XIV: 457,704-461,990 forward strand.

R64-1-1:BK006947.3

About this gene

This gene has 1 transcript (splice variant), 276 orthologues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
TOP2YNL088W_mRNA42871428aaYNL088W
 
Protein coding
P06786 NM_001182926.3
NP_014311.3

Gene-based displays