Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant [Source:SGD;Acc:S000005032]

TOR3, TRF3

Chromosome XIV: 457,704-461,990 forward strand.

R64-1-1:BK006947.3

This gene has 1 transcript (splice variant), 406 orthologues and is a member of 1 Ensembl protein family.

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