Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant [Source:SGD;Acc:S000005032]

Chromosome XIV: 457,704-461,990 forward strand.

This transcript has 1 exon, is annotated with 64 domains and features and is associated with 49 variant alleles.

This transcript is a product of gene YNL088W Show transcript tableHide transcript table