NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy [Source:SGD;Acc:S000004589]

Chromosome XIII: 28,266-29,807 reverse strand.

R64-1-1:BK006946.2

This gene has 1 transcript (splice variant), 311 orthologues, 2 paralogues and is a member of 2 Ensembl protein families.

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