Saccharomyces cerevisiae (R64-1-1)

NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy [Source:SGD;Acc:S000004589]


Chromosome XIII: 28,266-29,807 reverse strand.


About this gene

This gene has 1 transcript (splice variant), 821 orthologues and 3 paralogues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
P32340 -Ensembl Canonical