Saccharomyces cerevisiae (R64-1-1)
Description

NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy [Source:SGD;Acc:S000004589]

Location

Chromosome XIII: 28,266-29,807 reverse strand.

R64-1-1:BK006946.2

About this gene

This gene has 1 transcript (splice variant), 311 orthologues, 2 paralogues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
NDI1YML120C_mRNA1542513aaYML120C
 
Protein coding
P32340 NM_001182483.1
NP_013586.1

Gene-based displays