HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant [Source:SGD;Acc:S000004540]

Chromosome XIII: 115,734-118,898 reverse strand.

R64-1-1:BK006946.2

This gene has 1 transcript (splice variant), 301 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

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