Saccharomyces cerevisiae (R64-1-1)
Description

HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant [Source:SGD;Acc:S000004442]

Location

Chromosome XII: 1,032,627-1,035,764 forward strand.

R64-1-1:BK006945.2

About this gene

This gene has 1 transcript (splice variant), 301 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
HMG2YLR450W_mRNA31381045aaYLR450W
 
Protein coding
P12684 NM_001182338.1
NP_013555.1

Gene-based displays