HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant [Source:SGD;Acc:S000004442]

Chromosome XII: 1,032,627-1,035,764 forward strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant), 387 orthologues, 1 paralogue and is a member of 1 Ensembl protein family.

Show transcript tableHide transcript table