Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers [Source:SGD;Acc:S000004410]

Chromosome XII: 956,914-958,095 reverse strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant) and 341 orthologues.

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