mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication [Source:SGD;Acc:S000004126]

CTH2

Chromosome XII: 415,801-416,658 reverse strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant), 276 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

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