mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication [Source:SGD;Acc:S000004126]
CTH2
Chromosome XII: 415,801-416,658 reverse strand.
R64-1-1:BK006945.2
This gene has 1 transcript (splice variant), 153 orthologues and 1 paralogue.