Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins [Source:SGD;Acc:S000001702]

Chromosome XI: 14,485-15,708 forward strand.

R64-1-1:BK006944.2

This gene has 1 transcript (splice variant), 9 orthologues and 13 paralogues.

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