Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins [Source:SGD;Acc:S000001702]
Chromosome XI: 14,485-15,708 forward strand.
R64-1-1:BK006944.2
This gene has 1 transcript (splice variant), 9 orthologues and 13 paralogues.