RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant [Source:SGD;Acc:S000001632]

PRP26

Chromosome XI: 167,612-168,829 reverse strand.

R64-1-1:BK006944.2

This gene has 1 transcript (splice variant), 252 orthologues and is a member of 2 Ensembl protein families.

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