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Saccharomyces cerevisiae (R64-1-1)
Description

RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant [Source:SGD;Acc:S000001632]

Gene Synonyms

PRP26

Location

Chromosome XI: 167,612-168,829 reverse strand.

R64-1-1:BK006944.2

About this gene

This gene has 1 transcript (splice variant) and 381 orthologues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
DBR1YKL149C_mRNA1218405aaYKL149C
 
Protein coding
P24309 -Ensembl Canonical