RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant [Source:SGD;Acc:S000001632]
Chromosome XI: 167,612-168,829 reverse strand.
This transcript has 1 exon, is annotated with 17 domains and features, is associated with 32 variant alleles and maps to 29 oligo probes.
This transcript is a product of gene YKL149C Show transcript tableHide transcript table