Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves both isoprenylated and non-prenylated oligopeptides; contains multiple transmembrane spans; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and can complement yeast null mutant [Source:SGD;Acc:S000003878]

AFC1, PIO2

Chromosome X: 642,007-643,368 forward strand.

R64-1-1:BK006943.2

This gene has 1 transcript (splice variant) and 381 orthologues.

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