Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves both isoprenylated and non-prenylated oligopeptides; contains multiple transmembrane spans; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and can complement yeast null mutant [Source:SGD;Acc:S000003878]

Chromosome X: 642,007-643,368 forward strand.

This transcript has 1 exon, is annotated with 10 domains and features, is associated with 35 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YJR117W Show transcript tableHide transcript table