Saccharomyces cerevisiae (R64-1-1)
Description

DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress [Source:SGD;Acc:S000003626]

Location

Chromosome X: 262,757-265,051 reverse strand.

R64-1-1:BK006943.2

About this gene

This gene has 1 transcript (splice variant), 322 orthologues and is a member of 1 Ensembl protein family.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
DPB11YJL090C_mRNA2295764aaYJL090C
 
Protein coding
P47027 NM_001181523.1
NP_012445.1

Gene-based displays