Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability [Source:SGD;Acc:S000003567]

Chromosome X: 387,657-388,247 forward strand.

R64-1-1:BK006943.2

This gene has 1 transcript (splice variant), 338 orthologues and is a member of 1 Ensembl protein family.

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