Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3 [Source:SGD;Acc:S000001405]

LOM3, RAD25

Chromosome IX: 80,510-83,041 reverse strand.

R64-1-1:BK006942.2

This gene has 1 transcript (splice variant) and 398 orthologues.

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