Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress [Source:SGD;Acc:S000001197]

ESC4

Chromosome VIII: 402,966-406,178 forward strand.

R64-1-1:BK006934.2

This gene has 1 transcript (splice variant), 325 orthologues and is a member of 1 Ensembl protein family.

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