NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p [Source:SGD;Acc:S000003128]

Chromosome VII: 200,561-202,273 forward strand.

R64-1-1:BK006941.2

This gene has 1 transcript (splice variant), 1669 orthologues and 3 paralogues.

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