Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability [Source:SGD;Acc:S000003054]

Chromosome VII: 347,119-349,368 forward strand.

R64-1-1:BK006941.2

This gene has 1 transcript (splice variant), 321 orthologues and is a member of 1 Ensembl protein family.

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