Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability [Source:SGD;Acc:S000003054]
Chromosome VII: 347,119-349,368 forward strand.
R64-1-1:BK006941.2
This gene has 1 transcript (splice variant) and 34 orthologues.