Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability [Source:SGD;Acc:S000003054]

Chromosome VII: 347,119-349,368 forward strand.

This transcript has 1 exon, is annotated with 19 domains and features, is associated with 45 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YGL086W Show transcript tableHide transcript table