Saccharomyces cerevisiae (R64-1-1)
Description

Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress [Source:SGD;Acc:S000001923]

Synonyms

CTF7

Location

Chromosome VI: 207,452-208,297 forward strand.

R64-1-1:BK006940.2

About this gene

This gene has 1 transcript (splice variant), 208 orthologues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
ECO1YFR027W_mRNA846281aaYFR027W
 
Protein coding
P43605 NM_001179992.1
NP_116683.1

Gene-based displays