Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress [Source:SGD;Acc:S000001923]

Chromosome VI: 207,452-208,297 forward strand.

This transcript has 1 exon, is annotated with 5 domains and features, is associated with 43 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YFR027W Show transcript tableHide transcript table