Saccharomyces cerevisiae (R64-1-1)

Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood [Source:SGD;Acc:S000001917]

Gene Synonyms

AUT10, CVT18, NMR1, SVP1


Chromosome VI: 194,812-196,314 forward strand.


About this gene

This gene has 1 transcript (splice variant), 364 orthologues and 2 paralogues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
P43601 -Ensembl Canonical