Saccharomyces cerevisiae (R64-1-1)
Description

NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927]

Synonyms

MDP1, MUT2, NPI1, SMM1, UBY1

Location

Chromosome V: 410,189-412,618 forward strand.

R64-1-1:BK006939.2

About this gene

This gene has 1 transcript (splice variant), 305 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
RSP5YER125W_mRNA2430809aaYER125W
 
Protein coding
P39940 NM_001179015.3
NP_011051.3

Gene-based displays