Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during diauxic shift; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; ortholog of mammalian neutral sphingomyelinase type 2 [Source:SGD;Acc:S000000821]
Chromosome V: 192,797-194,230 forward strand.
R64-1-1:BK006939.2
This gene has 1 transcript (splice variant), 329 orthologues and is a member of 1 Ensembl protein family.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
ISC1 | YER019W_mRNA | 1434 | 477aa | YER019W | Protein coding | P40015 | - | Ensembl Canonical, |