Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002407]

Chromosome IV: 1,802-2,953 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 41 orthologues, 12 paralogues and is a member of 2 Ensembl protein families.

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