Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002407]
Chromosome IV: 1,802-2,953 forward strand.
R64-1-1:BK006938.2
This gene has 1 transcript (splice variant), 9 orthologues and 13 paralogues.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
COS7 | YDL248W_mRNA | 1152 | 383aa | YDL248W | Protein coding | Q07788 | - | Ensembl Canonical, |