Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis [Source:SGD;Acc:S000002375]

CSN5, JAB1

Chromosome IV: 68,997-70,319 reverse strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 236 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

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