Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication [Source:SGD;Acc:S000002341]

Chromosome IV: 133,437-134,723 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 419 orthologues and 3 paralogues.

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