Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype; [Source:SGD;Acc:S000000514]

VPL15, VPS23

Chromosome III: 105,696-106,853 reverse strand.

R64-1-1:BK006937.2

This gene has 1 transcript (splice variant), 326 orthologues and is a member of 1 Ensembl protein family.

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