Saccharomyces cerevisiae (R64-1-1)

Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN) [Source:SGD;Acc:S000000427]


Chromosome II: 668,663-670,297 reverse strand.


About this gene

This gene has 1 transcript (splice variant) and 185 orthologues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
P38319 -Ensembl Canonical