Saccharomyces cerevisiae (R64-1-1)
Description

Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN) [Source:SGD;Acc:S000000427]

Location

Chromosome II: 668,663-670,297 reverse strand.

R64-1-1:BK006936.2

About this gene

This gene has 1 transcript (splice variant), 265 orthologues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
TDP1YBR223C_mRNA1635544aaYBR223C
 
Protein coding
P38319 NM_001178571.3
NP_009782.3

Gene-based displays