Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN) [Source:SGD;Acc:S000000427]

Chromosome II: 668,663-670,297 reverse strand.

This transcript has 1 exon, is annotated with 9 domains and features, is associated with 50 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YBR223C Show transcript tableHide transcript table