ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1 [Source:SGD;Acc:S000000405]

Chromosome II: 623,576-624,211 forward strand.

R64-1-1:BK006936.2

This gene has 1 transcript (splice variant), 14 orthologues and is a member of 1 Ensembl protein family.

Show transcript tableHide transcript table