Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres [Source:SGD;Acc:S000000340]
ESR1, RAD31, SAD3
Chromosome II: 505,668-512,774 forward strand.
R64-1-1:BK006936.2
This gene has 1 transcript (splice variant), 292 orthologues and 4 paralogues.