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Saccharomyces cerevisiae (R64-1-1)

Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1) [Source:SGD;Acc:S000001523]

Gene Synonyms



Chromosome XI: 361,058-361,828 reverse strand.


About this gene

This gene has 1 transcript (splice variant), 355 orthologues and is a member of 1 Ensembl protein family.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
P32860 -Ensembl Canonical