Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000003330]
Chromosome VII: 682,566-687,458 reverse strand.
R64-1-1:BK006941.2
This gene has 1 transcript (splice variant) and 304 orthologues.