Saccharomyces cerevisiae (R64-1-1)
Description

Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda [Source:SGD;Acc:S000002454]

Gene Synonyms

HEM6

Location

Chromosome IV: 551,860-552,948 forward strand.

R64-1-1:BK006938.2

About this gene

This gene has 1 transcript (splice variant), 351 orthologues, 6 paralogues and is a member of 2 Ensembl protein families.

Show/hide columns (1 hidden)
  • Name
  • Transcript ID
  • bp
  • Protein
  • Translation ID
  • Biotype
  • UniProt
  • RefSeq
  • Flags
NameTranscript IDbpProteinBiotypeUniProtRefSeqFlags
HEM12YDR047W_mRNA1089362aa
 
Protein coding
P32347 -Ensembl Canonical

Showing the top 3 hits from Europe PubMed Central

PubMed IDTitleAuthorsJournal
30578666Extension of the yeast metabolic model to include iron metabolism and its use to estimate global levels of iron-recruiting enzyme abundance from cofactor requirements.Dikicioglu D, Oliver SG.Biotechnol Bioeng 116 (3) 2019
18156292Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine.Agarwal AK, Xu T, Jacob MR, Feng Q, Lorenz MC, Walker LA, Clark AM.Eukaryot Cell 7 (2) 2008
16607011Conserved fungal genes as potential targets for broad-spectrum antifungal drug discovery.Liu M, Healy MD, Dougherty BA, Esposito KM, Maurice TC, Mazzucco CE, Bruccoleri RE, Davison DB, Frosco M, Barrett JF, Wang YK.Eukaryot Cell 5 (4) 2006