NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927]

Chromosome V: 410,189-412,618 forward strand.

This transcript has 1 exon, is annotated with 51 domains and features, is associated with 20 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YER125W Show transcript tableHide transcript table